Lacunar Infarcts : Significance of Volume, Lesion Location and Risk Factors

J Korean Neurol Assoc > Volume 11(3); 1993 > Article

Journal of the Korean Neurological Association 1993;11(3): 302-309.

열공성 뇌색경증 : 병변체적, 위치, 위험인자에 관한 연구

김동권, 이상봉,김재문

충남대학교 신경과.

Lacunar Infarcts : Significance of Volume, Lesion Location and Risk Factors

Dong-Kueon Kim, M.D., Sang-Bong Lee, M.D., Jae-Moon Kim, M.D.

Department of Neurology, College of Medicine Choonnam National University

Abstract

We investigated 260 patients with the purpose of verifting the risk factors that determine lesion location and lesion volume. All the patients were subdibided into six lacunar syndrome subgroups (LSS) according to the clinical features, and also, into five lesion location subgroups(LSS) by neuroradiology findings. The common clinical syndromes were pure motor hemiparesis (32%) and sensorimotor stroke (30%). The mean lesion volume was large in pure sensory skoke and pure motor hem.paresis, and small in ataxic hemilaresis The common sites of lesion were internal capsule(32%) and basal ganglia(27%) In contrast with LSS, the risk factors and lesion volume were different among LLS. Patients with infratentorial lesion showed higher blood pressure than those with supratentorial lesion(p<0.05j. Lesion volume of corona radiata was greater than that of thalamus or internal capsule (p<005). Muliple lacunar lesions were associated with higher seurum hemoglobin concentration, men, and smoking (p<0.05). We suggest that (1) vlood pressure is of the contributing factors in determining the lesion location, (2) lesion volume is largest in lacunar infarction involving corona radiata, and(3) smol;ing is one of the important cause of multiple lacunar infarction.