A Case of Multiple Mononeuropathy Associated with Polyarteritis Nodosa

J Korean Neurol Assoc > Volume 10(3); 1992 > Article

Journal of the Korean Neurological Association 1992;10(3): 395-400.

결절성 다발동맥염에 동반된 말초신경병증 1예

이성훈, 노순기,송창원,이상익,박규현,김상욱

부산대학교 신경과.

A Case of Multiple Mononeuropathy Associated with Polyarteritis Nodosa

Sung-Hoon Lee, M.D., Soon-Ki Rho, M.D., Chang-Won Song, M.D., Sang-Ik Lee, M.D., Kyu-Hyun Park, M.D., Sang-Wook Kim, M.D.

Department of Neurology, College of Medicine, Pusan National University

Abstract

Polyarteritis nodosa(PAN) has been depicted as a necrotizing arteritis of small and medium-sized muscular arteries, affecting multiple organ systems throughout the body. The etiology of PAN remains unknown, but the histopathologic resemblance to chronic serim sickness has suggested an immune complex pathogenesis. The peripheral nervous system(PNS) is more frequently affected (in about 20-50% of patients) than the central nervous system(in about 10-20% of patients). Although multiple mononeuritis multiplex is generally considered to be the typical PNS manifestation of PAN, distal symmetrical polyneuropathy may occur more frequently than previous recognized. We report a case of polyarteritis nodosa with mononeuritis multiplex and distal symmetrical polyneuropathy, which was diagnosed by electrophysiological study and biopsies of muscle and sural nerve.