Numb-Chin Syndrome in Malignant Hematologic Diseases

J Korean Neurol Assoc > Volume 10(1); 1992 > Article

Journal of the Korean Neurological Association 1992;10(1): 89-92.

악성 혈액질환에서의 Numb-chin 증후군 7예

석승한, 선우일남,김승민,이선주,한지숙,고윤웅

연세대학교 신경과, 내과.

Numb-Chin Syndrome in Malignant Hematologic Diseases

Seung-Han Suk, M.D., Il-Nam Sunwoo, M.D., Seung-Min Kim, M.D., Sung-Ju Lee, M.D., Jee-Sook Lee, M.D., Jee-Sook Hahn, M.D., Yun-Woong Ko, M.D.

Department of Neurology and Internal Medicine, College of Medicine, Yoensei University

Abstract

'Num-chin syndrome', isolated mental neuropathy, is a rare manifestaion of malignant hernatologic diseases, but important sign for early diagnosis and prediction of clinical course and prognosis. Here we report 7 cases of numb-chin syndrome; one in leukemic transformation of malignant lymphoma, one in blastic crisis of chronic myelogenous leukemia and 5 in acute leukemia Two cases of acute leukemia revealed the 'numb-chin sign' in early course of disease before the diagnosis of leukemia and other three in aggravating state of acute leukemia. The therapeutic response and prognosis was poor and 5 cases expired in a few months.