Clinical Manifestations and Multimodality Evoked Potentials in Patients with Definite Multiple Sclerosis

J Korean Neurol Assoc > Volume 10(1); 1992 > Article

Journal of the Korean Neurological Association 1992;10(1): 49-58.

다발성경화증 환자에서의 임상 양상과 유발전위 검사 소견의 비교 관찰

허지희, 선우일남,박기덕,조필자

연세대학교 신경과. 이화여자대학교 내과. 국립의료원 신경과.

Clinical Manifestations and Multimodality Evoked Potentials in Patients with Definite Multiple Sclerosis

Ji-Hoe Heo, M.D., Il-Nam Sunwoo, M.D., Kee-Duk Park, M.D., Phil-Za Cho, M.D.

Department of Neurology, College of Medicine, Yoensei University. Department of Internal Medicine, College of Medicine, Ehwa Womans University, Department of Neurology, National Medical Center

Abstract

Twenty patients with clinically definite multiple sclerosis were seen at the Department of Neurology, Severance Hospital between 1984 and 1991 and their clinical features ar.d multimodality evoked potential findings were analyzed. We could not find any significant differences in sex ratio, age of onset, and clinical courses from the study results of Japanese and Western groups. However, visual disturbances at the onset and optic-spinal or optic-spinal-brainstem involvements, which are known to be characteristic features of oriental patients, were also noted to be the most common features in our study. Multimodality evoked potential studies were performed and abnorrnal recordings by at least one of the examinations were found in all but one patient. VEP yielded most frequent abnormalities Diagnostic yield of BAEP increased from overall 43% to 83% in cases having brainstem samploms or sings and the increase ＊as much higher than those seen in VEP of SSEP. Increase or increase in latency as occasionall noticed during follow up but majority of patients did not show significant changes in EP {indings. In one patient however. EP abnorrnalities showed improvement in 2 follow up exarninations during 4 years and 7 months despit the evident aggravation in clinical features. Evoked potentials can give valuable information in the diagnosis of multiple scierosis but further studies are necessary to evaluate their usefulness in the follow up examination.