Injection Sites and Doses in the Treatment of Cervical Dystonia with Botulinum A Toxin:A Preliminary Report

J Korean Neurol Assoc > Volume 9(3); 1991 > Article

Journal of the Korean Neurological Association 1991;9(3): 341-348.

경부 Dystonia 치료에서 보튤리눔 A독소 주사 위치 및 용량에 대한 예비적 조사

위봉애, 이광우,노재규,이상복,명호진

서울대학교 신경과.

Injection Sites and Doses in the Treatment of Cervical Dystonia with Botulinum A Toxin:A Preliminary Report

Bong Ae Wie, M.D., Kwang Woo Lee, M.D., Jae Kyu Roh, M.D., Sang Bok Lee, M.D., Ho Jin Myung, M.D.

Dep. Of Neurology, Seoul National University

Abstract

We administered local injections of botulinum A toxin to 15 patients wlth medically intratrable cervical dystonia Thirteen of the patients (87%) improved substantially (global effect>3 ; fiom -l = aggravated to +5 = markedly improved, fully functional, very happy with the results), with a mean total dose of 75.9 units. Of the 8 patients who reported pain, 7 (88%) had almost complete re!ief of pain. Only 6 of 15 (40%) patients had mild to moderate complications. More muscles had been injected in rotatocollis (mean, 5.2) than in laterocollis (mean, 3.0) (p<0.05). The global effects in rotatocollis (mean, 3.4) and laterocollis (mean, 3.3) were significantly better than anterocollis (mean, 1.5) (p<0.05). We conclude that botulinum A toxin is also effective in low doses when given in due consideration of the cervical muscle contraction patterns.