Sequential Changes and Prognostic Values of Electrophysiological Parameters in Guillain-Barre Syndrome

J Korean Neurol Assoc > Volume 9(1); 1991 > Article

Journal of the Korean Neurological Association 1991;9(1): 49-56.

Guillain-Barre Syndrome에서 전기생리적 기준척도의 시기적 변화 및 예후와의 상관관계

김승현, 홍승봉,이광우

서울대학교 신경과.

Sequential Changes and Prognostic Values of Electrophysiological Parameters in Guillain-Barre Syndrome

Seung Hyun Kim, M.D., Seung Bong Hong, M.D., Kwang Woo Lee*, M.D.

Dep. Of Neurology, Seoul National University

Abstract

The present study was designed to identify the sequential electrophysiological findings ant to determine the prognostic values of electrophysiological and clinical pararneters in patients with Guillain-Barre syndrome (GBS). Severely affected 42 subjects (Grade D,E). Who fulfilled the diagnostic criteria of GBS were selected. Twentynine patients were followed up at least 6 months (range 6-24 months) from the onset of neurologic syrnptorns. We analyzed 83 electrodiagnostic studies from 42 subjects. The sequential electrophysiological abnorrnalities were most marked at 3-4 weeks after the onset. At that time the most significant change was a decrease of CMAP amplitude. By stepwise discriminant analysis of several electrophysiological parameters, the three variables, of CMAP amplitude, distal conduction velocity; and F-wave latency were deterrnined to be significant pararneters. The accuracy of predicting the prognosis at 6 months was 82. 8%, when the classification functions were applied. Nlerefore the findings of early electrophysiological studies would be irnportant in understanding the serial pathophysiological changes and assessing the clinical outcorne of Guillain-Barre syndrorne