A Study of  Sympathetic Skin Response in Non-Insulin Dependent Diabetic Patients

J Korean Neurol Assoc > Volume 8(2); 1990 > Article

Journal of the Korean Neurological Association 1990;8(2): 289-298.

비인슐린의존성 당뇨병 환자에서의 교감신경 피부반응에 관한 연구

김광국, 황연미, 김종성 , 이기업, 명호진

울산대학교 신경과, 내과. 서울중앙병원 신경과, 내과. 서울대학교 ?신경과.

A Study of Sympathetic Skin Response in Non-Insulin Dependent Diabetic Patients

Kwang Kuk Kim, M.D., Youn Mee Hwang, M.D., Jong Sung Kim, M.D., Ki Up Lee, M.D*, Ho Jin Myung, M.D**

Dep. Of Neurology, College of Medicine, University of Ulsan, Asan Medical Center Dep. Of Internal Medicine, College of Medicine, University of Ulsan* Dep. Of Neurology, College of Medicine, Seoul National University**

Abstract

In order to examine the usefulness of the sympathetic skin response(SSR) as an indicator of autonomic dysfunction, we measured the amplitudes and latencies of the SSR in 64 consecutive non-insulin dependent diabetic patients, which were compared with those of 54 normal controls. The SSR on stimulation of median and posterior tibial nerves with EMG electrographer were correlated with nerve conductoin velocity(NCV) findings of median, posterior tibial and sural nerves and with beat-to-beat variation, measured as difference beeen maximum and minimum heart rate during deep breathing. Diabetic patients were also divided into 5 subgroups according to the symptoms of peripheral neuropathy, autonomic neuropathy and NCV findings for further comparisons. The results were as follows: 1. The shapes of the SSR were similar in the hand and the foot, but the amplitude was consistently greater in the hand than in the foot(p<0.001). The latency was shorter in the hand than in the foot(P<0.001). 2. The latencies of the foot and hand SSR in the diabetic patients were not significantly different from the normal controls. On the other hands, the amnplitude of the hand and foot SSR was significantly reduced compared to the control(p<0.001). 3. Of the patients with absent foot SSR, 20(59%) had two or more symptoms of aut- onomic involvement, whereas 14(14%) had no autonomic symptoms. These difference were significant(p