The Effect of Carbon Monoxide Intoxication on The Metabolites of Monoamine Neurotransmitters in Human Cerbrospinal Fluid

J Korean Neurol Assoc > Volume 8(2); 1990 > Article

Journal of the Korean Neurological Association 1990;8(2): 249-255.

일산화탄소중독이 뇌척수액 신경전달물질의 대사물질에 미치는 영향

김동권, 송홍기, 김주한, 정경천, 이용성

한양대학교 신경과, 생화학.

The Effect of Carbon Monoxide Intoxication on The Metabolites of Monoamine Neurotransmitters in Human Cerbrospinal Fluid

Dong Kwon Kim, M.D., Hong Ki Song, M.D., Ju Han Kim, M.D., Kyung Cheon Chung, M.D. Yong Sung Lee, M.D.*

Department of Neurology & Biochemistry* , College of Medicine, Hanyang University

Abstract

This study was done in order to show the effects of carbon rnonoxide (CO) induced hypoxia on the steps of metabolism of rnonoamine neurotransmitters. There were 9 patients exposed to CO and 5 patients of control group. We evaluated their cerebrospinal fluid within 24 hours after CO exposure. And we measured the amounts of 5-hydroxy-indole acetic acid (5-HIAA) and homovanillic acid (HVA) with high performance liquid chromatography (HPLC). In the CO exposure group, the levels of 5-HIAA and HVA were reduced compared with the control group. It was thought that the changes in the levels of 5-HIAA and HVA were due to the transient decrease in monoamine oxidase activity in acute hypoxia.