Peripheral Neuropathy Associated with Castheman's Disease

J Korean Neurol Assoc > Volume 8(1); 1990 > Article

Journal of the Korean Neurological Association 1990;8(1): 159-165.

Castleman병 (거대 림프절 증식증)에 동반된 말초신경병중

손영호, 김승민,박수철,정원영,김호근,지제근

연세대학교 신경과, 병리학. 서울대학교 병리학.

Peripheral Neuropathy Associated with Castheman's Disease

Young Ho Sohn, M.D., Seung Min Kim, M.D., Soo Chul Park, M.D., Won Young Jung, M.D., Ho Geun Kim, M.D., Je Geun Chi, M.D.

Department of Neurology, Yonsei University College of Medicine Department of Pathology, Wonju College of Medicine, Yonsei University Department of Pathology, College of Medicine, Seoul National University

Abstract

Castleman's disease, or giant Iymph node hyperplasia, is a Iymphoproliferative disorder which is characterized by Iymphoid hyperplasia with capillary proliferation, and divide histologically into two 0varieties, hyaline vascular and plasmal cell form. Some system manifestations are occasionally accompanied with the diseases, but peripheral neuropathy is a rarely reported manifestatlon of them and not in Korea. The present report describes a 40 year old female patient who had been admitted to Yonsei university medicai center because of progressive quadriparesis. On examination, she revealed various other manifestations such as hyperpigmentation, Iymphadenopathy, pitting edema, and bilateral papilledema. The electrophysiologic studies and sural nerve biopsy showed severe sensori-motor peripheral neuropathy showing features of mixed demyelinatlon and axonal degeneration. The Iymph node biopsy showed features compatible with Castleman's disease of hyaline vascular type. The recovery was poor over four month period despite of treatment with corticosterold.