A Case of Delayed Peripheral Polyneuropathy Induced by Organophosphorus Intoxication

J Korean Neurol Assoc > Volume 6(2); 1988 > Article

Journal of the Korean Neurological Association 1988;6(2): 261-267.

유기인제 중독에 의한 지연성 다발성말초신경병증 1예

정원영, 이명식,최일생,지제근

연세대학교 신경과. 서울대학교 병리학.

A Case of Delayed Peripheral Polyneuropathy Induced by Organophosphorus Intoxication

Won-Young Jung,M.D., Myung-Sik Lee,M.D., Il-Saing Choi,M.D. Je Geun Chi,M.D.

Department of neurology, Yong Dong Severance Hospital, College of Medicine, Yonsei University Department of Pathology, College of medicine, Seoul National University

Abstract

Delayed peripheral polyneuropathy caused by organophosphorus intoxication is not uncommon. This is a case report of 32 years old female with peripheral polyneuropathy which is appeared two weeks after organophosphorus poisoning. It is characterized by calves pain followed by minmal sensory change and predominant motor weakness affecting the distal part of the limbs. The electrophysiologic and pathologic studies support the clinical diagnosis. The exact pathogenesis is still debated, but phosphorylation of neurotoxic esterase (NTE), followed by "aging" process was suspected to play a role in the development of axonal degeneration.