Brainstem Auditory Evoked Potentials in Diphenylhydantion Sodium (DPH) Intoxication

J Korean Neurol Assoc > Volume 6(1); 1988 > Article

Journal of the Korean Neurological Association 1988;6(1): 64-70.

Diphenylhydantion(DPH)중독 환자에서의 뇌간청각 유발전위(BAER)에 관한 연구

박성호, 이광우,명호진

서울대학교 신경과.

Brainstem Auditory Evoked Potentials in Diphenylhydantion Sodium (DPH) Intoxication

Seong Ho Park, M.D., kwang Woo Lee, M.D., and Ho Jin Myung, M.D.

Department of Neurology, College of Medicine, Seoul National University

Abstract

DPH is a firstlined antiepileptic drug and its toxic symptoms are mainly due to cerebellar and brainstem dysfunction. We tested 22 BAERs in 11 patients with DPH intoxication at the Department of Neurology of Seoul National University Hospital from Nov. 1986 to Oct. 1987. BAER IPLs were measured and analysed, including follow-up tests in 4 patients, and the results obtained were as follows. 1. Nine (81.8%) of 11 patients showed abnormal findings in BAER (biliateral in six, unilateral in three) but 2 showed no abnormal, findings. 2. Prolongation of I-III IPL was noted in 14 of total tests (N=22), III-V in only one. Prolongation of I-V IPL was noted 12 tests but seemed to be due to prolongation of I-III IPL. 3. Follow-up tests in 4 patients showed that abnormal IPLs tended to be normalized by decreasing serum DPH levels in three but persisted in one. In colclusion, 9 of 11 patients with DPH intoxication showed BAER abnormalities and main abnormalities were prolongation of I-III IPL. Considered with the results of follow-up tests, for confirmation of its reversibility, large-scaled and prospective study with strict follow-up seemed to be required.