Chronic Polyneuropathy with Monoclonal Gammopathy of Undetermined Significance

J Korean Neurol Assoc > Volume 4(2); 1986 > Article

Journal of the Korean Neurological Association 1986;4(2): 239-245.

Undetermined Significance의 단클론성 감마글로블린 혈증과 연관된 만성 다발성신경병증

이한보, 김종성, 이광우, 이상복, 명호진 ,지제근

서울대학교 신경과, 병리학.

Chronic Polyneuropathy with Monoclonal Gammopathy of Undetermined Significance

Han-Bo Lee, M.D., Jong-Sung Kim, M.D., Kwang-Woo Lee, M.D., Sang-Bok Lee,M.D., Ho-Jin Myung, M.D., Je-Geun Chi, M.D.*

Department of Neurology & Pathology*, College of Medicine, Seoul National University

Abstract

Diseases of the peripheral nervous system are one of the most difficult subjects in neurology partly in that specific etiologies are often not found. Among peripheral neuropathies of unknown causes, an association of monoclonal gammopathies has been observed. Monoclonal gammopathies are disorders characterized by proliferation of a single clone of plasma cell that produces monoclonal proteins. Here we report two cases of chronic sensorimotor polyneuropathy with monoclonal gummopathy of undetermined significance, who showed no evidences of multiple myeloma, macroglobulinemia, systemic amyloidosis, or other neoplasms. One case is also associated with hyperthyroidism and cryoglobulinemia.