A Case of Rhabdomyolysis with Acute Renal Failure Due to Acute CO Poisoning

J Korean Neurol Assoc > Volume 3(1); 1985 > Article

Journal of the Korean Neurological Association 1985;3(1): 83-89.

급성 일산화탄소중독 후 발생한 근용해 및 급성 신부전 1례

정수영, 윤인혁, 김명호, 고영혜, 김종만, 이중달

한양대학교 신경과, 병리학.

A Case of Rhabdomyolysis with Acute Renal Failure Due to Acute CO Poisoning

Soo-Young Jeong, M.D.,Jung-Dal Lee. M.D., Jung-Man Kim, M.D., Young-Hyae Ko, M.D., Myung-Ho Kim, M.D., In-Hyuk Yoon,M.D.

Department of Pathology, Hanyang University

Abstract

The authors studied one case with rhabdomyolysis associated with acute renal failure, which followed acute CO intoxication. Oliguria, hyperkalemia developed within one day of rhabdomyolysis on left extremities. During the first three days of hospitalization, rapid increase in serum BUN, serum creatinine and serum muscle enzymes (CPK, LDH, GPT, GOT) were noted. Renal failure was controlled by artifiral kidney. Several areas of increased uptake of technetium-99m DP were noticed on bone scan. Electron microscopic examinations of biopsied muscle consist of disarrangement of myofibrils, loss or destruction of Z-line, difficulties in distinguishing A-band from I-band, and swelling of mitochondrias. These findings suggest that acute CO poising may be followed by severe muscle destruction and renal damage.