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J Korean Neurol Assoc. 1999;17(2):228-234.
- Striatal dopamine transporter changes in patients with essential tremor and idiopathic Parkinson’s disease
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Yong Duk Kim, M.D.1, Joo Hyuk Im, M.D.2, Hee Joung Kim, M.D.3 Myung Sik Lee, M.D.1
1Department of Neurology, Yongdong Severance Hospital, 3Department of Radiology
Yonsei University College of Medicine
2Department of Neurology, Ulsan University College
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Department of Neurology, Yongdong Severance Hospital,
Yonsei University College of Medicine,
146-92 Dogok-Dong, Kangnam-Gu, Seoul, Korea
Tel : (02) 3497-3322 Fax : (02) 3462-5904
E-mail : Myungs56@yumc.yonsei.ac.kr
- 본태성 진전 환자와 파킨슨씨 병 환자에서
선조체 도파민 수송체 변화
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김용덕, 임주혁 김희중 이명식
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연세대학교 의과대학 영동 세브란스병원 신경과* , 연세대학교 의과대학 진단방사선과학교실**
울산대학교 의과대학 서울중앙병원 신경과학교실2
- Abstract
- Background
s: There have been controversies about the association between essential tremor (ET) and Parkinson’s disease. To examine the nigrostriatal dopaminergic neurons in patients with ET, we measured the striatal dopamine transporter levels with [123I] N-(3-iodopropene-2-yl)-2?-carbomethoxy-3?-(4-chlorophenyl) tropane(IPT) single photon emission computed tomography (SPECT). Methods: This study included nine patients with postural tremor, six patients with postural and rest tremor, 11 patients with idiopathic Parkinson’s disease, and 21 age matches controls. Using triple headed gamma camera, brain SPECT scans were performed at 115 and 120 minutes after the injection of 6.23?1.37mCi(range 5-10mCi) of I123 labeled IPT. We averaged two images. Regions of interest were drawn on the middle set image at the level of basal ganglia (BG) for each subject. Amounts of striatal dopamine transporter were measured by calculating the ratio between the average counts of the basal ganglia minus occipital cortex (OCC) and the counts of the OCC((BG-OCC)/OCC). Results: The mean of (BG-OCC)/OCC ratios of 9 isolated postural tremor patients (3.60?0.83) was not statistically different from that of the controls (P>0.05). However, the mean of (BG-OCC)/OCC ratios of 4 patients with postural and rest tremor (2.61?0.18) was significantly lower than that of the controls (P<0.01). Four of the six patients with postural and rest tremor had mean ratios lower than 2.0 standard deviations from the mean of the controls. Conclusion: In their later clinical courses, some patients with postural tremor may develop rest tremor in association with a damage in the nigrostriatal dopaminergic system.
Key Words : Isolated postural tremor, Rest tremor, Parkinson’s disease, I123 IPT SPECT
Keywords :
- 초록
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