| 암환자의 뇌혈관질환 |
| 이지용, 권준범 양현덕 이성익 한범기 문준식 이성수 |
| 연세대학교 원주의과대학 원주기독병원 신경과 |
| Cerebrovascular Diseases in Cancer Patients |
| Ji-Yong Lee, M.D., Joon-Bum Kwon, M.D., Hyun-Duk Yang, M.D., Seong-Ik Lee, M.D.,
Bum-Gi Han, M.D., Joon-Shik Moon, M.D., Sung-Soo Lee, M.D. |
| Department of Neurology, Wonju Christian Hospital, Wonju College of Medicine, Yonsei University |
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| Abstract |
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Background : The association of vascular thrombosis with cancer has been known since Trousseau’s description of
venous thrombophlebitis in patients with carcinoma. Previous studies, mainly autopsy-based, have suggested that the stroke spectrum in cancer patients differ from that of the general population. However, no studies that address this
question in the adult oncological population from a clinical perspective are available in Korea. We therefore assessed
the clinical features of cerebrovascular diseases in cancer patients. Methods : We retrospectively analyzed 44 cases of
symptomatic cerebrovascular disease in cancer patients who were admitted to the Wonju Christian Hospital from
January 1993 to June 1998 by reviewing their charts and brain CT or MRI; primary cancer, the interval from a cancer
diagnosis to the occurrence of stroke, the incidence of hypercoagulability as an infarction cause, the location and size of
the infarction, the type of hemorrhage, and the prognosis. Results : The mean age was 62.3 years. Twenty eight cases
(63.6%) were ischemic stroke and sixteen cases (36.4%) were hemorrhagic stroke. The most common primary cancer
of infarction and hemorrhage was stomach cancer. In ischemic patients, the most common cell type of cancer was ade-nocarcinoma
and six cases (21.4%) were considered to have hypercoagulability as a cause. In hemorrhagic patients,
seventy percent of patients with coagulopathy died in the hospital or were discharged moribundly. C o n c l u s I o n s :
Although hypercoagulability is present to a greater extent in the patient population than in the general population, it
appears that conventional stroke risk factors account for the majority of cerebral ischemic events in the adult cancer
population. Cancer patients with intracranial hemorrhage owing to coagulopathy reveal poor prognosis.
J Korean Neurol Assoc 17(6):792~796, 1999
Key Words : Cancer, Cerebrovascular disease, Hypercoagulability |
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