| 특발성 파킨슨증에서 우울증의 빈도와 그에 영향을 미치는 임상요소들 |
| 이 준홍, 이명식, 손영호, 김경환, 김진수 |
| 연세대학교 신경과 |
| The Clinical Factors Affecting Depression and its Frequency in ?Idiopath Parkinsonism
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| Joon Hong Lee, M.D., Myung Sik Lee, M.D., Young Ho Sohn, M.D., Kyung Hwan Kim, M.D., Jin Soo Kim, M.D. |
| Department of Neurology, College of Medicine, Yonsei University |
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| Abstract |
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The purpose of this study was to investigate the frequency of depression and the relationships between various clinical features and depression in the patients with idiopathic parkinsonism. We included 113 patients of idiopathic parkinsonism who had any three of resting tremor, rigidity, bradykinesia, impaired postural reflexes or any one of the first three displaying asymmetry without definite brain lesion on brain imaging studies or metabolic derangement. We used Beck depression inventory, and the results were compared with those of 70 normal controls.
The following results were obtained:
1.The patients with idiopathic parkinsonism had more severe depression than normal
controls. If we@ consider the cut-point scores for depression as more than 21points of
Beck depression inventory scores, the frequency of depression in idiopathic parkinsonism
was 44. 1%.
2.The scores of the BDI questionare representing somatic symptoms were increased in
the patient group, whether they had mild or severe parkinsonian deficits. The patients
who had more severe parkinsonian deficits had higher scores. However, those
representing mood and self-reproach symptoms were increased only in the late stage of
idiopathic parkinsonism.
3.The severe motor symptoms, particularly bradykinesia and rigidity, poor responsiveness
to L-dopa treatment, longer the duration of disease, were the factors correlated with
severe depression. However the current age, age of onset, whether treated or untreated,
and whether sy7rnptonis affected predominantly right or left side of the body, were not
correlated with the severity of depression.
On the basis of the results, when we regard no tremorous symption and the poor
responsiveness to L-dopa treatment as the clinical features of idiopahtic parkinsonism,
we suspect the tendency that the patients with idiopathic parkinsonism may have more
severe depression than those with idiopathic P-qrkinson's disease. |
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