J Korean Neurol Assoc > Volume 21(5); 2003 > Article

Journal of the Korean Neurological Association 2003;21(5): 468-472.

"증후성 내경동맥 및 중뇌동맥 뇌경색 환자에서 Acetazolamide 부하 Tc-99m ECD 뇌관류 SPECT로 측정한 뇌혈관예비능의 비교"

김은희 , 황양하 안병철 정두교 서정규 박성파

경북대학교 의과대학 신경과학교실, 핵의학교실†, 국립부곡병원 신경과

"Cerebrovascular Reserve Measured by Acetazolamide-challenged Tc-99m ECD Brain Perfusion SPECT in Symptomatic Internal Carotid Artery and Middle Cerebral Artery Disease"

Eun-Hee Kim

"Department of Neurology and Nuclear Medicine†, School of Medicine, Kyungpook National University, Department of Neurology, Bugok National Hospital"

Abstract

"Background: Hemodynamic evaluation of the brain may be helpful for the identification of a risk of stroke in patients with middle cerebral artery (MCA) or internal carotid artery (ICA) steno-occlusive disease. The aim of this study was to evaluate the hemodynamic state in patients with steno-occlusive disease of ICA or MCA on the base of MRI/MRA and acetazolamide (ACZ)-challenged Tc-99m ECD brain perfusion SPECT findings.
Methods: An analysis of 68 patients who underwent MRI/MRA and ACZ-challenged Tc-99m ECD brain perfusion SPECT was performed. We divided these patients into two groups - MCA and ICA steno-occlusions. R e s u l t s: The cerebrovascular reserve (CVR) was impaired in 18 of 32 (56.3%) MCA disease patients (20 stenosis and 12 occlusions), and in 19 of 36 (52.8%) ICA disease patients (20 stenosis and 16 occlusion). The CVR was impaired in 22 of 28 (78.6%) occlusive patient, whereas in 15 of 40 (37.5%) stenotic patient (p<0.01). The insular lesion was more commonly involved in the occlusion group (54%) than in the stenosis group (15%) (p<0.01). C o n c l u s I o n s: There was no difference in CVR between MCA and ICA steno-occlusion groups. Incidence of impaired CVR was higher in occlusion group than stenosis group.Key Words: Cerebral infarction, Middle cerebral artery, Internal carotid artery, SPECT"