Myasthenia Gravis in Two Brothers with Identical HLA Genotype

J Korean Neurol Assoc > Volume 17(3); 1999 > Article

Journal of the Korean Neurological Association 1999;17(3): 452-455.

동일한 HLA 유전형을 가진 형제에서 발생한 중증근무력증

김제, 송희정*, 김재문

충남대학교 의과대학 신경과학교실, 삼성서울병원 신경과

Myasthenia Gravis in Two Brothers with Identical HLA Genotype

Jei Kim, Hee-Jung Song*, Jae-Moon Kim, MD,

Department of Neurology, Chungnam National University Hospital 640 Daesa-dong, Joong-ku, Taejon, 301-721, Korea

Abstract

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction having multigene control. Correlation with human leukocyte antigen (HLA) genotype in MG had been reported in sporadic and familial cases. We investigated HLA genotype of two myasthenic brothers, at ages 13 and 15 years old. There was no family history of myasthenia gravis. Their ages of onset were 10 and 15 years of age, respectively. Identical subtypes in HLA analyses were found, A30, A31, B13, B61, Cw3, Cw6, DRB1*04, DRB1*07, DQA1*02, DQA1*03, DQB1*03, DQB1*02 in both of them. We report two myasthenic siblings with identical HLA type that has not been reported previously. 동일한 HLA 유전형을 가진 형제에서 발생한 중증근무력증 J Kor Neurol Ass 17(3):452 ~ 455, 1999 *Address for correspondence Jei Kim, M.D. Department of Neurology, Key Words : Familial myasthenia gravis, HLA genotype, Autoimmune disease