산발성 크로이츠펠트-야콥병에서
혈전색전증의 혈전용해치료

J Korean Neurol Assoc > Volume 27(4); 2009 > Article

Journal of the Korean Neurological Association 2009;27(4): 405-408.

Thrombolytic Therapy of Pulmonary Thromboembolism in Probable Sporadic Creutzfeldt-Jakob Disease

장준영, 정진헌 장영희 김상윤

서울대학교 의과대학 신경과학교실, 분당서울대학교병원 신경과

산발성 크로이츠펠트-야콥병에서 혈전색전증의 혈전용해치료

Jun-Young Chang

Department of Neurology, Seoul National University College of Medicine, Seoul, Korea Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea

Abstract

The effect of intravenous recombinant tissue plasminogen activator for patients with Creutzfeldt-Jakob disease (CJD) has yet to be determined. A woman with rapidly progressive cognitive decline, cerebellar dysfunction, and extrapyramidal symptoms, diagnosed as probable sporadic CJD, was complicated with pulmonary thromboembolism and systemic hypotension. Her vital signs were restored without brain parenchymal hemorrhage after intravenous thrombolysis. The presence of diffuse brain lesions in CJD did not increase the hemorrhagic complications associated with intravenous thrombolysis, which differs from an ischemic vascular event.Key Words: Sporadic CJD, Pulmonary thromboembolism, Intravenous thrombolysis