Pathogenesis of Anti-MAG Antibody Associated with Demyelinating ?Peripheral Neuropathy ; Expression of Anti-MAG Antibody in ?Ebstein-Barr Virus Transformed Lymphocytes of Umbrical Cord

J Korean Neurol Assoc > Volume 13(1); 1995 > Article

Journal of the Korean Neurological Association 1995;13(1): 39-46.

탈수초성 말초신경 병변에 연관된 항-MSG항체의 발병기전; 태아 ?림프구에서의 항 -MAG 항체 발현

이광우, 김지수, 이성현, 이근호, 주인수

서울대학교 신경과, 단국대학교 신경과, 아주대학교 신경과

Pathogenesis of Anti-MAG Antibody Associated with Demyelinating ?Peripheral Neuropathy ; Expression of Anti-MAG Antibody in ?Ebstein-Barr Virus Transformed Lymphocytes of Umbrical Cord

Kwang Woo Lee, M.D., Ji Soo Kim, M.D., Sung Hyun Lee, M.D., Keun Ho Lee, M.D., In Soo Ju, M.D.

Department of Neurology, Seoul National University, DanKook University and Ajou University Medical School

Abstract

It is not unconimm that the monoclonal gammopathies occur in patients with demyelinating peripheral neuropathy. The IgM.-protein from those patients reacted with peripheral nerve myelin, which was first identified as the MAG (myelinassociated glycoprotein). In this study the authors tried to understand the pathogenetic mechanism of anti-MAG antibod by studying the expression of the anti MAG antibody in Epstein-Barr virus transformed lymphocytes of umbrical cord. The positive bands for anti-NMG antibody were found in 10 out of 320 sera of peripheral neuropathies by the thin layer chromatography of the glycolipids from bovine peripheral myelin. The positive anti-MAG expressions were found in 5 of 31 supernatant wells from EB virus transformed lymphocytes of umbrical cords, which tended to. Develop the antibody activity in the supernatants cultured more than ten days. The study indicates. In part that the anti-MAG antibody may be occurred by the autoimmune mechanism as the antibodies are expressed m the EB virus transformed lymphocytes which have never been exposed to foreign antigens so far However the automimune mechanism can be supported more by knowing the mcreased frequency of CD5 positive B cells in cases with high titer of anti-MAG antibodies