Relationship between Pachymeningeal Enhancement on Brain MRI and CSF leakage on Radioisotope Cisternography in Patients with Orthostatic Headache

J Korean Neurol Assoc > Volume 18(1); 2000 > Article

Journal of the Korean Neurological Association 2000;18(1): 38-43.

기립성 두통 환자에서 뇌자기공명영상의 수막 조영증강 소견과 방사성동위원소 뇌조조영술의 뇌척수액 누출 소견간의 관계

오윤민, 김장성

아주대학교 의과대학 신경과학교실

Relationship between Pachymeningeal Enhancement on Brain MRI and CSF leakage on Radioisotope Cisternography in Patients with Orthostatic Headache

Youn Min Oh, M.D., Jang Sung Kim, M.D.

Department of Neurology, College of Medicine Ajou University

Abstract

B a c k g r o u n d : In orthostatic headache (OH) associated with low cerebrospinal fluid (CSF) pressure, loss of CSF vol-ume reflected by pachymeningeal enhancement (PCE) on brain magnetic resonance image (MRI) has been suggested as a pathogenenesis according to Monro-Kellie rule. We attempted to test the following hypotheses; 1) OH is caused by loss of CSF volume, 2) CSF volume loss in OH is caused by hyperabsorption of CSF or 3) by decreased production of CSF. M e t h o d s : Nineteen patients with OH were recruited. Lumbar puncture, brain MRI and radioisotope cisternogra-phy (RIC) were performed in all of them. We evaluated duration of headache from onset to first evaluation, presence of PCE on MRI and CSF leakage (CSFL) on RIC. Firstly, we compared duration of headache between patients with and without PCE. Secondly, between those with and without PCE, we analyzed presence of CSF fistula and demonstration of CSFL on RIC. R e s u l t s : Mean duration (16.1 ±19.6) of headache in 13 patients with PCE (66.7%) was significantly longer than in those without PCE (P=0.036). Among 19 patients, CSF fistula was detected in 13 patients (72%) and CSFL in 16 patients (88.9%). There was no significant difference in CSF fistula presence (P=0.114) and in demonstra-tion of CSFL between those with and without PCE. In 16 patients, delayed appearance of radioisotope along cerebral interhemispheric and sylvian regions was shown on RIC. C o n c l u s I o n s : Pain in OH may be caused by CSF volume loss, however, whether CSF volume loss is caused by CSF hyperabsorption or decreased production remains to be clarified. J Korean Neurol Assoc 18(1):38~43, 2000 Key Words : Headache, Cerebrospinal Fiuid, Cerebrospinal Fiuid pressure