지역사회 거주 노인에서 인지기능과 아포지질단백질 E
유전자형의 연관성: 고령군 운수면 지역 조사

J Korean Neurol Assoc > Volume 27(4); 2009 > Article

Journal of the Korean Neurological Association 2009;27(4): 362-368.

Association of Apolipoprotein E Gene Polymorphism With Cognitive Function of the Elderly Residents in a Rural Community

권오대, 최소영 박재한 윤창효 권혁환 신임희a

대구가톨릭대학교 의과대학 신경과학교실, 의학통계학교실a

지역사회 거주 노인에서 인지기능과 아포지질단백질 E 유전자형의 연관성: 고령군 운수면 지역 조사

Oh Dae Kwon

Department of Neurology and Medical Statistics,a Catholic University of Daegu School of Medicine, Daegu, Korea

Abstract

Background: It is not clear whether polymorphism of the apolipoprotein E (ApoE) gene influences the cognition of community residents. The aim of this study was to establish the association between ApoE gene polymorphism and cognitive function in an elderly rural community in Korea.
Methods: A total of 388 subjects aged 65 and over were recruited. Demographic characteristics, past history of illness, and scores on the Korean version of the Mini Mental State Examination (K-MMSE), the Geriatric Depression Scale ? Short Form (GDS-S), and the Korean version of Instrumental Activities of Daily Living (K-IADL) were evaluated. The lipid profile and ApoE genotype were sampled from 377 of the participants.
Results: Of the entire cohort, 75% had less than 6 years of education, and 30% were illiterate. The frequencies of the ApoE ε2, ApoE ε3, and ApoE ε4 alleles were 48 (6.6%), 372 (86.9%), and 49 (6.5%), respectively. The K-MMSE score was much lower in those with two ApoE ε3 alleles than in those with only one ( p=0.046). However, the numbers of ApoE ε2 alleles (p=0.976) and ApoE ε4 alleles (p=0.934) carried by the individual were not associated with K-MMSE score. Both K-IADL (p<0.001) and GDS-S (p<0.001) scores were significantly correlated with K-MMSE score. Grouping of the participants into three groups according to K-MMSE score (i.e., 0?17 , 18?24, and 25?30) also revealed that this score was correlated with K-IADL score (p<0001), GDS-S score (p<0.001), and the ApoE ε3 allele (p=0.035).
Conclusions: These results suggest that the ApoE ε3 allele has a negative influence on cognitive function (K-MMSE) in this rural community. Surprisingly, we were unable to detect any relationship between the ApoE ε4 allele and cognitive function. There was a positive correlation between K-MMSE, K-IADL, and GDS-S scores. Key Words: Apolipoprotein E genotype, Mini mental state examination, Instrumental activities of daily living, Geriatric depression scale