| 파킨슨병 환자의 말초 혈액 단핵구에서
D3와 D5 도파민 수용기 mRNA 발현 |
| 최철희, 손영호, 최선아, 박동철, 곽용태, 최인홍*, 김진수 |
| 연세대학교 의과대학 신경과학 교실 및 뇌연구소, 미생물학 교실 |
| D3 and D5 Dopamine Receptor mRNA Expression in Peripheral Blood
Mononuclear Cells from Patients with Parkinson’s Disease |
| Chulhee Choi, M.D., Young Ho Sohn, M.D., Sun Ah Choi, M.D.,
Dong Chul Park, M.D., Yong Tae Kwak, M.D., In-Hong Choi, M.D.*,
Jin-Soo Kim, M.D, |
| Department of Neurology, Yonsei University College of Medicine
C.P.O. Box 8044, Seoul, 120-752, Korea |
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| Abstract |
Background: Among 5 subfamilies of dopamine receptors (DAR), D3 and D5 DAR are expressed on peripheral
blood mononuclear cells (PBMC). Recently, those DARs have been reported to change in Parkinson’s disease (PD).
Methods: We measured the DAR mRNA expression in PBMC from 15 PD patients who had never taken antiparkinson
medication, and 16 age-matched healthy people by reverse transcription and quantitative competitive polymerase chain
reaction. The β-actin mRNA expression was also measured to evaluate the relative expression of DAR mRNA.
Results:
The D3 and D5 DAR mRNA expression was not different between patients and controls. In patients, no significant cor-relation
was found between DAR mRNA expression in PBMC and clinical variables such as severity and duration of
symptoms, and patients’ age.
Conclusions: We confirmed the presence of D3 and D5 DAR in PBMC. However, their
mRNA expressions were not influenced by the disease process of PD.
J Kor Neurol Ass 17(3):359 ~ 364, 1999
Key Words : Parkinson’s disease, Peripheral blood mononuclear cell, Dopamine receptor, messenger RNA, PCR |
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