| 고용량 및 저용량 ticlopidine의 혈소판 응집억제 효과 비교: 예비연구 |
| 김제, 이훈복, 송희정*, 이태용**, 김재문 |
| 충남대학교 의과대학 신경과학교실, 예방의학교실**,
삼성서울병원 신경과 |
| Comparison of Antiplatelet Aggregation Effect between the High-Dose and Low-Dose Ticlopidine: A Preliminary Study |
| Jei Kim, Hoon-Bok Lee, Hee Jung Song*, Tae-Yong Lee**, Jae-Moon Kim
Department of Neurology and Preventive Medicine**, College of Medicine,
Chungnam National University,
Department of Neurology, Samsung Medical Center* |
| Department of Neurology, Chungnam National University Hospital
640 Daesa-dong, Joong-ku, Taejon, 301-721, Korea |
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| Abstract |
Background: To investigate the efficacy of antiplatelet activity of low dose ticlopidine, we compared the antiplatelet
effect of low dose ticlopidine with a high dose.
Methods: Fourteen healthy volunteers were divided into two series.
Volunteers in series I were medicated ticlopidine 250 mg twice a day (group 1) for first 7 days. After drug free interval
for another 7 days, single dose of ticlopidine 250 mg a day (group 2) was medicated for the third 7 days. Same medica-tion
schedule was taken with different doses in series II, single dose of 250 mg ticlopidine (group 3) for the first 7 days,
and divided dose of ticlopidine 250 mg a day (group 4) for the third 7 days after medication free interval of 7 days.
Platelet aggregation effect was evaluated by optical method using ADP and collagen reagent at before and after the
medication schedule. Differences of platelet aggregation effect between the four groups were analyzed.
Results: Five
and 4 could accomplish the full medication schedule of two groups in each series. Mean of platelet aggregation effect
of group 1 (44.4%) was more decreased than other groups, 61.2% in group 2, 71.0% in group 3, and 62.7% in group 4.
However, there was no significant differences of platelet aggregation effect by nonparametric statistical analysis
between group 1 and 2, 3 and 4 in each series.
Conclusions: This finding suggests that single low dose ticlopidine may
have the similar antiplatelet aggregation effect as the high dose one.
J Kor Neurol Ass 17(3):347 ~ 351, 1999
Key Words : Low dose ticlopidine, High dose ticlopidine, Platelet aggregation effectBackground: To investigate the efficacy of antiplatelet activity of low dose ticlopidine, we compared the antiplatelet
effect of low dose ticlopidine with a high dose.
Methods: Fourteen healthy volunteers were divided into two series.
Volunteers in series I were medicated ticlopidine 250 mg twice a day (group 1) for first 7 days. After drug free interval
for another 7 days, single dose of ticlopidine 250 mg a day (group 2) was medicated for the third 7 days. Same medica-tion
schedule was taken with different doses in series II, single dose of 250 mg ticlopidine (group 3) for the first 7 days,
and divided dose of ticlopidine 250 mg a day (group 4) for the third 7 days after medication free interval of 7 days.
Platelet aggregation effect was evaluated by optical method using ADP and collagen reagent at before and after the
medication schedule. Differences of platelet aggregation effect between the four groups were analyzed.
Results: Five
and 4 could accomplish the full medication schedule of two groups in each series. Mean of platelet aggregation effect
of group 1 (44.4%) was more decreased than other groups, 61.2% in group 2, 71.0% in group 3, and 62.7% in group 4.
However, there was no significant differences of platelet aggregation effect by nonparametric statistical analysis
between group 1 and 2, 3 and 4 in each series.
Conclusions: This finding suggests that single low dose ticlopidine may
have the similar antiplatelet aggregation effect as the high dose one.
J Kor Neurol Ass 17(3):347 ~ 351, 1999
Key Words : Low dose ticlopidine, High dose ticlopidine, Platelet aggregation effect |
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