J Korean Neurol Assoc > Volume 20(3); 2002 > Article

Journal of the Korean Neurological Association 2002;20(3): 279-282.

"중추신경계 Langerhans 조직구 증식증 1예: 뇌 MRI 소견 및 임상 경과"

강규식 , 김한준 이경민

서울대학교 의과대학 신경과학교실

"A Case of Central Nervous System Langerhans Cell Histiocytosis: Brain MRI Findings and Clinical Course"

Kyusik Kang, M.D.

Department of Neurology, College of Medicine, Seoul National University

Abstract

"A 28-year-old man with Langerhans cell histiocytosis of the gastric wall and hypophysial infundibulum had received local radiation therapy to the infundibulum. Eight months later he presented with left inferior temporal quadrantanopsia of the left eye. Brain MRI revealed multiple nodular enhancing lesions involving brainstem, left external capsule, both temporal lobes, prechiasmatic optic nerves and basal ganglia. After dexamethasone chemotherapy there had been partial remission. During tapering dexamethasone the symptom aggravated and then despite etoposide chemotherapy the size and number of lesions increased.Key Words : Langerhans cell histiocytosis, Brain magnetic resonance imaging, Central nervous system"