| 카바마제핀 서방형 제제의 단일경구부하 후의 혈중농도와 부작용 |
| 김병건 배희준 장인진 † 박성호*이상건*, 김병건 배희준 장인진 † 박성호*이상건* |
| 을지의과대학교 을지병원 신경과학교실 서울대학교 의과대학 신경과학교실*,약리학교실 † |
| The Serum Levels and Side Effects of Single Oral Loading of Controlled-Release Carbamazepine |
| Byung-Kun Kim, M.D., Hee-Joon Bae, M.D., In-Jin Jang, M.D. † , Seong-Ho Park, M.D.*, Sang-Kun Lee, M.D.* |
| Department of Neurology , Eulji University School of Medicine, Eulji Hospital Departments of Neurology* and Pharmacology † , College of Medicine, Seoul National University |
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| Abstract |
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Background : Effective oral loading of carbamazepine (CBZ) is very important as it is the most often administered drug for partial and generalized seizures. The pharmacokinetics and tolerability of a single oral loading of controlled-release form of carbamazepine (CBZ-CR) were assessed in 38 adult patients at risk for seizure. Methods : CBZ-CR was administered to 38 adults (22 had had CBZ just before entry into the study and 16 had not) at a dosage of 20 mg/kg as a single loading. Side effects and serum levels of CBZ and CBZ-10,11-epoxide (CBZ-E) were evaluated at 0, 2, 4, 6, 8, 12, 18, 24 h after the loading. Correlations between the frequency of side effects and other parameters (maxium serum concentration : Cmax, time to maximum concentration Tmax and area under the concentration time curve (AUC) of CBZ and CBZ-E) were also assessed. Results : Mean CBZ serum levels (percentage of subjects with level > 4 μg/ml shown in parenthesis) were 0.0 (0%), 3.2 (30%), 6.1 (79%), 7.2 (92%), 7.7 (95%), 7.7 (95%), 7.7 (95%) and 7.1 μg/ml (95%) at 0, 2, 4, 6, 8, 12, 18 and 24 h after loading. Cmax and Tmax were 8.42 μg/ml and 13.2 h respective-ly. Although side effects developed in 15 patients (39%), there were no significant neurotoxic side effects. The frequen-cy of the history of CBZ use was not different (p<0.05) in the two groups (one had side effects, another had not). Cmax, Tmax, and AUC of CBZ and CBZ-E were also not different (p<0.05). Conclusions : A single oral loading dose of CBZ-CR provides therapeutic serum concentrations quickly (in most patients within 6h) and is well tolerated. Rapid loading with CBZ-CR appears to be a useful alternative for the management of patients with a high risk of seizures. J Korean Neurol Assoc 18(3):276~280, 2000
Key Words : Anticonvulsants, Carbamazepine, Dosage, Pharmacokinetics, Toxicity |
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