Olanzapine-induced Neuroletpic Malignant Syndrome

J Korean Neurol Assoc > Volume 18(2); 2000 > Article

Journal of the Korean Neurological Association 2000;18(2): 249-251.

Olanzapine에 의해 발생한 신경이완제 악성증후군

곽용태, 구민성*

용인효자병원 신경과,신촌세브란스병원 정신과

Olanzapine-induced Neuroletpic Malignant Syndrome

Yong Tae Kwak, M.D., Min-Seong Koo, M.D.*

Department of Neurology, Yongin Hyoja Geriatric Hospital Department of Psychiatry, College of Medicine, Yonsei University*

Abstract

We report a case of atypical neuroleptic malignant syndrome (NMS) induced by olanzapine. It was expected that this atypical agent would not cause dystonia or NMS due to its unique mechanism of action with attenuated anti-dopamin-ergic activity and potentiated antiserotonergic activity, as well as other anti-cholinergic activity. We report the case of a 74-year-old male patient with Alzheimer’s disease in whom signs and symptoms consistent with NMS developed fol-lowing 2 weeks of olanzapine therapy. The patient presented with fever, changes in mental status, tremor, and rigidity. His laboratory findings were significant for increased serum creatine phosphokinase. The NMS subsided after treat-ment and the restart of olanzapine therapy was performed successfully. There have been few reported cases of olanzap-ine-induced NMS. Health care providers should be aware of the risk of olanzapine-induced NMS. J Korean Neurol Assoc 18(2):249~251, 2000 Key Words : Neuroleptic malignant sydrome, Olanzapine, Alzheimer’s disease