Methylenetetrahydrofolate Reductase Gene Polymorphism in Korean Patients with Migraine or Ischemic Stroke

J Korean Neurol Assoc > Volume 23(2); 2005 > Article

Journal of the Korean Neurological Association 2005;23(2): 176-180.

한국인 편두통 및 허혈성 뇌졸중 환자에서 C677T MTHFR 유전자의 다형성

김병건, 김만호* 강라미* 배희준 구자성 권오현 이종은† 이상수

을지의과대학교 을지병원 신경과, 서울대학교 의과대학 신경과학교실*, DNA Link†, 충북대학교 의과대학 신경과학교실‡

Methylenetetrahydrofolate Reductase Gene Polymorphism in Korean Patients with Migraine or Ischemic Stroke

Byung-Kun Kim

Department of Neurology, Eulji University School of Medicine, Eulji Hospital, Seoul; Department of Neurology, Seoul National University Hospital*, DNA Link, Inc.†, Seoul; Department of Neurology, Chungbuk National University Hospital‡, Cheongju, Korea

Abstract

Background: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been implicated in both migraine and ischemic stroke. The homozygous C677T mutation in the MTHFR gene was more frequent in the Japanese and Turkish migraineurs than in the control group. Positive associations have also been found in ischemic stroke. The purpose of this study is to investigate the role of MTHFR C677T polymorphism in Korean patients with migraine or ischemic stroke.
Methods: We analyzed the allele frequencies and genotype of MTHFR C677T polymorphism in 115 patients with migraine, 213 with cerebral infarction, and 73 controls.
Results: There was no significantly increased frequency of homozygosity for the T677 allele in both of the diagnostic groups, compared to the controls.
Conclusions: Our results suggest that MTHFR gene C677T polymorphism is unlikely to play a major role in the pathogenesis of migraine or ischemic stroke in Korean patients.KeyWords:Migraine, Stroke, Homocysteine, Methylenetetrahydrofolate reductase, Polymorphism