Observations on Cerebrospinal Fluid Studies in Systemic Lupus Erythematosus

J Korean Neurol Assoc > Volume 5(2); 1987 > Article

Journal of the Korean Neurological Association 1987;5(2): 166-170.

전신성 홍반성 낭창의 뇌척수액 검사 소견

김장성, 선우일남, 김기환

연세대학교 신경과.

Observations on Cerebrospinal Fluid Studies in Systemic Lupus Erythematosus

Jang-Sung Kim, M.D., Il-Nam Sunwoo, M.D., Ki-Whan Kim, M.D

Department of Neurology, College of Medicine, Yonsei University

Abstract

To determine the effects of central nervous system (CNS) involvement in systemic Lupus erythematosus (SLE) on cerebrospinal fluid (CSF), CSF studies of 35 cases of SLE (22 cases with CNS involvement and 13 cases without CNS involvement) were analyzed and compared with 20 normal CSF studies. The mean values of several CSF parameters were significantly changed in the group of SLE with CNS involvement (increased protein, white blood cell (WBC) counts and pressure, and decreased glucose contents), but not in the group of SLE without CNS involvement. In 22 case of SLE with CNS involvement, 10 cases (45.5%) were more than 4 WBC's in CSF, 12 cases (54.6%) more than 40 mg/dl of CSF protein and 8 cases (36.4%) less than 40 mg/dl of CSF glucose. CSF pressure was increased more than 200 mm CSF in 41.2%. On the other hand, in 13 cases of SLE without CNS involvement, the CSF studies were almost normal except 4 cases (30.8%) of more than 40 mg/dl in CSF protein.