Epstein-Barr Virus Related Polymorphic Posttransplantation
Lymphoproliferative Disease in a Patient with Latent Infection of JC
Virus

J Korean Neurol Assoc > Volume 30(2); 2012 > Article

Journal of the Korean Neurological Association 2012;30(2): 136-140.

잠복기 JC 바이러스에 감염된 환자에서 발생한 엡스타인-바바이러스와 연관된 이식후다형성림프증식증

빈창훈, 박민수

영남대학교 의과대학 신경과학교실

Epstein-Barr Virus Related Polymorphic Posttransplantation Lymphoproliferative Disease in a Patient with Latent Infection of JC Virus

Chang Hun Bin

Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea

Abstract

Posttransplantation lymphoproliferative disease (PTLD) is an important form of posttransplant malignancy and is typically associated with Epstein-Barr virus (EBV). Progressive multifocal leukoencephalopathy (PML) is a demyelination disease caused by infection of the John Cunningham (JC) virus. Both PTLD and PML occur in the setting of an immunosuppressive state. Differentiating PTLD from PML is important because PTLD can be treated by reducing immunosuppressant agents or anti-B-cell antibody therapy. We report a case of EBV-related PTLD in a patient with latent JC virus.