Pseudohypoparathyroidism Presented With Seizure

J Korean Neurol Assoc > Volume 29(2); 2011 > Article

Journal of the Korean Neurological Association 2011;29(2): 133-135.

간질 발작으로 발현한 거짓부갑상샘저하증

황민호, 정유리 강규식 박종무 권오현 김병건 이정주

을지대학교 을지병원 신경과

Pseudohypoparathyroidism Presented With Seizure

Minho Hwang

Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Korea

Abstract

Pseudohypoparathyroidism (PHP) is a rare clinical syndrome characterized by hypocalcemia, hyperphosphatemia and increase of serum parathyroid hormone in association with unique clinical features. We recently experienced a typical PHP type Ia patient who presented with recurrent seizure and muscle spasms and electroencephalogram (EEG) showed generalized spike-and-wave discharges. With the correction of hypocalcemia, seizures did not recur and epileptiform discharges disappeared. We suggest that the possibility of PHP should be considered in patients with seizures showing hypocalcemia and hyperphosphatemia. KeyWords:Pseudohypoparathyroidism, Seizures, Electroencephalogram