Cisplatin-Induced Encephalopathy With Status Epilepticus

J Korean Neurol Assoc > Volume 31(2); 2013 > Article

Journal of the Korean Neurological Association 2013;31(2): 122-124.

뇌전증지속상태를 동반한 시스플라틴(cisplatin) 유발 뇌병증

김나영, 배성윤 이세진

영남대학교 의과대학 신경과학교실

Cisplatin-Induced Encephalopathy With Status Epilepticus

Na-young Kim

Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea

Abstract

A 75-year old man with esophageal cancer presented with mental status change and seizures. He was under cisplatinand developed several times of generalized tonic-clonic seizures. The EEG (electroencephalography) showed triphasic waves and slowed background activity. He was diagnosed with status epilepticus and encephalopathy caused by cisplatin. He was treated with anticonvulsants and cisplatin was replaced by docetaxel. His mentality recovered completely and he had no more seizure. We conclude that physician using cisplatin should be aware of this rare complication. Key Words: Cisplatin, Status epilepticus, Encephalopathy, Triphasic wave