A Case of Rhabdomyolysis after Doxylamine Overdose

J Korean Neurol Assoc > Volume 18(1); 2000 > Article

Journal of the Korean Neurological Association 2000;18(1): 119-120.

Doxylamine Succinate 과다복용에 의한 횡문근 융해

김종철, 이상암

울산대학교 의과대학 서울중앙병원 신경과

A Case of Rhabdomyolysis after Doxylamine Overdose

Jong-Chul Kim, M.D., Sang-Ahm Lee, M.D.

Department of Neurology, Asan Medical Center, College of Medicine, Ulsan University

Abstract

We report a case of non-traumatic rhabdomyolysis after overdose of doxylamine succinate. A 22-year-old woman with reactive depression had an overdose of doxylamine with suicidal intent. She had decreased mental state, confu-sion, convulsion, vomiting, tachycardia, pupil dilatation, and ocular flutter. Serum creatine phosphokinase concentra-tion was 6,752 IU/L initially, increased to maximum (165,590 IU/L) at the third day, and then rapidly decreased and returned to normal 2 weeks after intoxication. Acute renal failure occurred but was resolved without hemodialysis. Rhabdomyolysis associated with renal failure is a rare but serious complication after doxylamine overdose. J Korean Neurol Assoc 18(1):119~120, 2000 Key Words : Rhabdomyolysis, Doxylamine, Antihistamine, Renal failure