A Case with Corticobasal Degeneration Showing Asymmetric Apraxia with Concordant Hypometabolism on FDG-PET

J Korean Neurol Assoc > Volume 18(1); 2000 > Article

Journal of the Korean Neurological Association 2000;18(1): 109-112.

비대칭적인 실행증을 보이고 F D G -P E T에서 비대칭적 대사감소가 확인된 피질-기저핵 변성

장 혁, 박성욱 ·박현영 ·김요식 ·조광호

원광대학교 의과대학 신경과학교실

A Case with Corticobasal Degeneration Showing Asymmetric Apraxia with Concordant Hypometabolism on FDG-PET

Hyuk Jang, M.D., Seong-Wook Park, M.D., Hyun-Young Park, M.D., Yo-Sik Kim, M.D., Kwang-Ho Cho, M.D.

Department of Neurology, School of Medicine, Wonkwang University

Abstract

Corticobasal degeneration (CBD) is characterized by asymmetric clinical manifestations including asymmetrical apraxia, alien limb movement and Parkinsonian symptoms. Cognitive function is relatively normal in the early course of illness. We report a 59 years old right-handed male with CBD. He showed asymmetrical ideomotor apraxia, alien limb movement and extrapyramidal symptom, such as cogwheel rigidity and bradykinesia, that were more severe in the right hand. These symptoms have deteriorated progressively for 2 years, but the cognitive function was relatively pre-served. Brain MRI revealed atrophic changes in both parietal lobes. FDG-PET showed an asymmetrical hypometabo-lism in supplementary motor area, parietal lobe, thalamus and basal ganglia, which was more severe in the left than the right hemisphere. J Korean Neurol Assoc 18(1):109~112, 2000 Key Words : Corticobasal degeneration, Apraxia, FDG-PET