J Korean Neurol Assoc > Volume 29(3); 2011 > Article
Journal of the Korean Neurological Association 2011;29(3): 231-233.
항 Signal Recognition Particle (신호인식입자) 항체와 연관된 근병증
홍현정, 선우일남 신하영 김세훈a 조정희b 김승민
연세대학교 의과대학 신경과학교실, 병리학교실a, 국립건강보험공단 일산병원 신경과b
Myopathy with Anti Signal Recognition Particle Antibody
Hyun Jung Hong
Departments of Neurology, Pathologya, Yonsei University College of Medicine, Seoul, KoreaDepartment of Neurologyb, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea
Abstract
Myopathies associated with anti-signal-recognition particle (SRP) antibodies usually present with severe muscle weakness and exhibit necrotizing myopathy with little inflammation pathologically. Here we report a case of a 61-year-old man who presented with subacute progressive proximal muscle weakness, dysarthria, and dysphagia. Although polymyositis was expected clinically, muscle biopsy revealed myopathic changes with degenerating fibers without definite inflammation. Further laboratory study revealed that the patient was positive for anti-SRP antibodies. KeyWords:Idiopathic inflammatory myopathies, Autoantibodies, Signal recognition particle
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