The Effect of Latent Syphilis on Carotid Intima-Media Thickness in Acute Ischemic Stroke Patients

J Korean Neurol Assoc > Volume 25(1); 2007 > Article

Journal of the Korean Neurological Association 2007;25(1): 64-69.

급성기 허혈성 뇌졸중 환자에서 잠복 매독이 경동맥 내막-중막 두께에 미치는 영향

김태용, 신동진 김재혁 이영배

가천의과학대학교 신경과학교실

The Effect of Latent Syphilis on Carotid Intima-Media Thickness in Acute Ischemic Stroke Patients

Tae-Yong Kim

Department of Neurology, Gachon University, Gil Medical Center, Incheon, Korea

Abstract

Background: Neurosyphilis develops into ischemic stroke due to the occlusion of intracranial arteries, which has the histopathological change of intracranial syphilitic arteritis. There might be an association between a latent syphilis and arterial changes before the neurosyphilis develops. We evaluated the relationship between the latent syphilis and the carotid intima-media thickness (IMT) in acute ischemic stroke patients to study whether the latent syphilis affected pathological arterial changes.
Methods: Retrospectively consecutive 96 acute ischemic first ever stroke patients were selected from the Gachon stroke registration from January 2003 to May 2005. The latent syphilis group was made up of 44 patients and the non-syphilis group matched in the age and the sex and consisted of 52 patients. The stroke subtype was classified by TOAST classification.
Results: The mean carotid IMT of the latent syphilis group (3.06±3.78 mm right, 2.68±3.39 mm left) was thicker than that of the non-syphilis group (1.49 mm±2.37 mm right, 1.43±1.99 mm left)(p<0.05). The hs-CRP was more elevated in the latent syphilis group than the non-syphilis group (1.6±2.2 mg/dl, 1.0±2.3 mg/dl respectively) (p<0.05). There were no significant differences of in each of the risk factors between the two groups.
Conclusions: Our results showed the patients with latent syphilis had thicker carotid IMT, and a higher level of hs-CRP than the non-syphilis patients. It could be possible that the latent syphilis attributed to the pathological changes by the inflammation in the extracranial carotid artery.KeyWords:Latent syphilis, Carotid intima-media thickness (IMT), hsCRP, Inflammation