A Case of Probable Creutzfeldt-Jakob Disease with Coexistence of the Features of Hashimoto Encephalopathy

J Korean Neurol Assoc > Volume 22(4); 2004 > Article

Journal of the Korean Neurological Association 2004;22(4): 406-409.

하시모토 뇌병증 소견을 동반한 크로이츠펠트-야콥병

조양제, 박찬희 백종원 신혜원 박정화† 박수철 김현옥* 김용선

연세대학교 의과대학 신경과학교실, 진단검사의학교실*, 한림대학교 일송생명과학연구소

A Case of Probable Creutzfeldt-Jakob Disease with Coexistence of the Features of Hashimoto Encephalopathy

Yang-Je Cho

Departments of Neurology and Diagnostic Laboratory Medicine*, Yonsei University College of Medicine, Seoul; Ilsong Institute of Life Science, Hallym University†, Korea

Abstract

Hashimoto encephalopathy shares common clinical features with Creutzfeldt-Jakob disease and must be regarded as a differential diagnosis because of its good prognosis. We report a case of Hashimoto encephalopathy, which had not been recognized before the diagnosis of Creutzfeldt-Jakob disease. The electroclinical findings were compatible with probable Creutzfeldt-Jakob disease and coexistence of Hashimoto thyroiditis was supported by high titers of anti-thyroid microsomal antibody and cytopathologic findings. Hashimoto encephalopathy was not improved, which was most likely due to the coexistence of Creutzfeldt-Jakob disease.Key Words: Hashimoto encephalopathy, Creutzfeldt-Jakob disease, Differential diagnosis