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Journal of the Korean Neurological Association 2003;21(6): 563-572.
신경면역학의 이해: 다발성경화증과 길랑-바레증후군을 중심으로
박재현 ,
인제대학교 의과대학 상계백병원 신경과
"Understanding of Neuroimmunology: Multiple sclerosis and Guillain-Barr? syndrome"
Jae Hyeon Park
Department of Neurology, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Korea
Neuroimmunology is a rapidly expanding field in the medicine and there has been great advancement in the understanding of the pathogenesis of autoimmune diseases during the past decade. In neurology, immune mechanism has been implicated in the pathogenesis of more than twenty neurological diseases. The understanding of the immunological mechanism of these diseases has helped clinicians in management of these diseases. In many neurological diseases with immunological deterioration, multiple sclerosis and Guillain-Barre syndrome are relatively common diseases that share common features like demyelination. But multiple sclerosis is a disease of central nervous system and Guillain-Barr? syndrome is a syndrome developed in peripheral nervous system. This review will describe the recent advances in clinical immunology with regard to general aspects of autoimmune diseases of neurological system, pathogenesis of two common autoimmune diseases, multiple sclerosis and Guillain-Barr? syndrome. Key Words: Neuroimmunology, Multiple sclerosis, Guillain-Barr? syndrome