| Oxcarbazepine을 복용한 간질환자의 인지기능:신경심리검사 및 사건유발전위 |
| 박성파, 황양하 김정일 김종열 권순 정보우 김지언 서정규 |
| "경북대학교 의과대학 신경과학교실, 소아과학교실, 포천중문의과대학교부속 구미 차병원 신경과학교실,
대구가톨릭대학교 의과대학 신경과학교실" |
| "Cognitive Function in Epileptic Patients Treated with Oxcarbazepine:
Neuropsychologic test and Event-related Potential" |
| Sung Pa Park, M.D |
| "Department of Neurology and Pediatrics, Kyungpook National University
Department of Neurology, Pochon CHA University, Kumi CHA General Hospital, School of Medicine, Catholic University of Daegu" |
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| Abstract |
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"Background : Antiepileptic drugs (AEDs) may impair cognitive function in epileptic patients. Oxcarbazepine (OXC,
Trileptal ) is a recently developed AED. The effect of oxcarbazepine (OXC, Trileptal ) monotherapy on cognitive function
was studied prospectively in patients with partial or generalized epilepsies. Methods : A total of 22 patients were
started on OXC monotherapy and 18 out of them completed a 1-year follow-up. Nine patients didn t have any previous
history of anticonvulsant medications. OXC was administered 600 to 1,500 mg twice daily after 10 to 14 days of titration
period. We used neuropsycological assessments (verbal learning and memory, visual memory, digit span, Trail
Making, and verbal fluency) and auditory event-related potentials (P300) for the evaluation of cognitive function before
and 1 year after OXC treatment. Results : Twelve patients became seizure free and 6 patients showed the reduction in
monthly seizure frequency. The adverse effects of medication were mild weight gain, GI problems, dizziness, fatigue
and headache etc., but they were transient. In particular one patient experienced a feeling of alertness and clear-headedness
with continuation of the medication. Neuropsycological tests showed a significant improvement of performance in
verbal learning, word recognition and Trail Making test of type A. P300 latencies were significantly shortened, but their
amplitudes were not changed. Conclusions : Even though many variable factors such as the age at onset of epilepsy,
etiology of epilepsy, seizure frequency, seizure type, epileptic process itself and dosage of antiepileptic drugs influence
cognitive function of epileptic patients, OXC at least does not seem to be harmful or rather slightly beneficial for cognitive
functions. Key Words : Cognitive function, Epilepsy, Oxcarbazepine, P300" |
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