| "뇌졸중 환자의 헬리코박타 감염과
단핵구 CD14 수용체 유전자의 다형성" |
| 박문호, 이승환 김병조 박건우 이대희 박민규 |
| 고려대학교 의과대학 신경과학교실 |
| "Helicobacter pylori Infection and Monocyte CD14
Receptor Gene Polymorphism in Stroke Patients" |
| "Moon Ho Park, M.D., Seung Hwan Lee, M.D., Byung Jo Kim, M.D.,
Kun Woo Park, M.D., Dae Hie Lee, M.D., Min Kyu Park, M.D." |
| Department of Neurology, College of Medicine, Korea University |
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| Abstract |
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"Background : There is accumulation data indicating that infective pathogens such as Helicobacter pylori, Chlamydia
pneumonia, cytomegalovirus may be linked to the atherosclerosis of cerebral vessels. As an independent contributing
factor, the complex of the CD14 receptor and lipopolysaccharides plays an important role in activating
monocytes/macrophages. Especially, C(-260)→T polymorphism of the CD14 receptor may be a risk factor for athero-sclerotic
disease. In the present study, we investigated a possible association between Helicobacter pylori infections as
well as the polymorphism of the CD14 receptor and ischemic cerebrovascular disease. M e t h o d s : A total of 109
patients and 103 controls were included in the study. Patients were divided into stroke subgroups based on pathogenic
mechanisms. Helicobacter pylori seropositivity was determined from serum samples. The genomic DNA was isolated
from the whole blood and the CD14 receptor genotypes were determined by polymerase chain reactions. R e s u l t s :
Helicobacter pylori seropositivity was more common in the patients group than in the control group (79.8% vs 65.0%,p=0.012). Moreover, Helicobacter pylori seropositivity was more common in the subgroup with large artery disease
(96.0%, p=0.012). The distribution of CD14 receptor genotypes was as follows: patients, T/T 19.3%, T/C 60.6%, C/C
20.2%; controls, T/T 16.5%, T/C 63.1%, C/C 20.4%. There was no significant difference among the polymorphisms of the CD14 receptor. However, in a subgroup with low atherosclerotic risk (normotensive nondiabetics), there was a ten-dency
of more frequent T/T genotypes. Conclusions : Chronic Helicobacter pylori infections might be a risk factor for ischemic cerebrovascular disease. However, the polymorphism of the CD14 receptor was not associated with an increased risk for ischemic cerebrovascular disease. J Korean Neurol Assoc 19(4):337~341, 2001 Key Words : Helicobacter pylori, CD14, Polymorphism (genetics), Cerebrovascular accident" |
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