J Korean Neurol Assoc > Volume 19(3); 2001 > Article
Journal of the Korean Neurological Association 2001;19(3): 232-238.
초기 파킨슨병의 임상척도와 뇌파의 비선형성의 관계
주은연, 김지현 채승희 김응수*박기덕 최경규
이화여자대학교 의과대학 목동병원 신경과학교실,이화 의과학센터,대전대학교 전자공학부*
The Relation of Clinical Scale and Non-Linearity of EEG in Early Parkinson’s Disease
Eun-yeon Joo, M.D., Ji-hyun Kim, M.D., Seung-hee Chae, M.D., Eung -su Kim, Ph.D.*, Ki-duck Park, M.D., Kyoung-gyu Choi, M.D.
Department of Neurology, Ewha Medical Research Center, College of Medicine, Ewha Womans University Division of Elec. Info. & Comm. Engineering, Daejon University*
Abstract
"Background : Many recent studies based on non-linearity have been performed to quantify the complex behavior of the brain in order to understand the pathophysiology of Parkinson’s disease (PD). Methods : We calculated the Fractal dimension (FD) and Lyapunov exponent (L1), the non-linear biologic signals, by digital EEG using ‘CHASIM’ pro-gram, non-linear times series signal simulator and then compared the UPDRS score with the degree of atrophy in the substantia nigra upon brain MRI and EEG data respectively. All subjects (N=20) showed definite hemiparkinsonism. Results : Upon EEG analysis, a strong positive correlation was noted between FD of the left hemispheric electrodes (FP1,F3,T3,T5) and the UPDRS scores in left-sided symptomatic patients. Additionally, positive correlations were noted between the ipsilateral MRI index ratio in the right and left-sided symptomatic patients and respective UPDRS scores. Conclusions : These results suggested that thalamocortical drive is reduced in the contralateral hemisphere to parkinsonian symptoms and thalamocortical or corticothalamic glutaminergic projection in the ipsilateral hemisphere is increased in the early stage of Parkinson’s disease. Additionally, hemiparkinsonim may primarilly cause anatomic and functional changes in the contralateral hemisphere and a compensatory effect in the ipsilateral hemisphere at the same time. We suggest that disease duration may be a compensating factor and of which require further investigation. We hope that our results will aid the understanding of the specific patterns of dysfunction and treatment effects by non-lin-ear EEG measures and anatomic changes of the substantia nigra through continuous follow up of the patients. J Korean Neurol Assoc 19(3):232~238, 2001 Key Words : Non-linearity of EEG, UPDRS score, Substantia nigra, Parkinson’s disease"


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