| "마우스 뇌에서 Lipopolysaccharide,Interleukin (IL)-12/IL-2
및 Interferon Gamma의 T Cell Chemokine 유도성" |
| 김지언, 이동국 ·서성일*·백원기*·서민호*·권택규*·박종욱*·서정규† |
| 대구가톨릭대학교 의과대학 신경과학교실,계명대학교 의과대학 의과학연구소*,경북대학교 의과대학 신경과학교실† |
| "T Cell Chemokine Inducibility of Lipopolysaccharide,
Interleukin (IL)-12/IL-2 and Interferon Gamma in Mouse Brain" |
| "Ji-Eun Kim, M.D., Dong-Kuck Lee, M.D., Seong-Il Suh, M.D.*, Won-Ki Baek, M.D.*,
Min-Ho Suh, M.D.*, Taeg-Kyu Kwon, Ph.D.*, Jong-Wook Park, M.D.*, Chung-Kyu Suh, M.D.†" |
| "Department of Neurology, School of Medicine, Catholic University of Daegu,
Institute of Medical Science, Keimyung University School of Medicine*
Department of Neurology, School of Medicine, Kyungpook National University
†" |
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| Abstract |
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"Background : Interferon gamma (IFN-γ)-inducible protein 10 (IP-10) and monokine induced by IFN-γ(Mig) are
members of CXC-chemokine family, that are produced from macrophage/monocyte activated by IFN-γ. These
chemokines especially recruit activated T cell into inflammatory site. Here, we studied effect of lipopolysaccharide
(LPS), interleukin (IL)-12/IL-2 or IFN-γon induction of MIG and IP-10 in mouse brain. Methods : In order to evaluate
Mig and IP-10 gene expression in brain, we injected LPS, IFN-γor IL-12/IL-2 into mice intraperitoneally, and mea-sured
chemokine message in brain by RT-PCR. Results : In vivo injection of LPS induced Mig and IP-10 gene expres-sion
in brain of normal mice and IFN-γknockout mouse, however, in vivo injection of IL-12/IL-2 induced Mig and IP-10
gene expression in only the brain of normal mice. IFN-γinduced chemokine expression in cultured brain cells, but
anti-inflammatory drugs did not block IFN-γeffects. Conclusions : Immune stimulating agents, LPS or IL-12/IL-2 or
IFN-γ, can induce T cell chemokine gene expression in brain cells, and these chemokines may play a role in T cell infil-tration
in various brain diseases.
J Korean Neurol Assoc 19(2):155~162, 2001
Key Words : Chemokine, Lipopolysaccharide, Interleukin-12, Interleukin-2, Interferon gamma, Brain" |
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