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Journal of the Korean Neurological Association 2001;19(2): 155-162.
"마우스 뇌에서 Lipopolysaccharide,Interleukin (IL)-12/IL-2 및 Interferon Gamma의 T Cell Chemokine 유도성"
김지언, 이동국 ·서성일*·백원기*·서민호*·권택규*·박종욱*·서정규†
대구가톨릭대학교 의과대학 신경과학교실,계명대학교 의과대학 의과학연구소*,경북대학교 의과대학 신경과학교실†
"T Cell Chemokine Inducibility of Lipopolysaccharide, Interleukin (IL)-12/IL-2 and Interferon Gamma in Mouse Brain"
"Ji-Eun Kim, M.D., Dong-Kuck Lee, M.D., Seong-Il Suh, M.D.*, Won-Ki Baek, M.D.*, Min-Ho Suh, M.D.*, Taeg-Kyu Kwon, Ph.D.*, Jong-Wook Park, M.D.*, Chung-Kyu Suh, M.D.†"
"Department of Neurology, School of Medicine, Catholic University of Daegu, Institute of Medical Science, Keimyung University School of Medicine* Department of Neurology, School of Medicine, Kyungpook National University †"
Abstract
"Background : Interferon gamma (IFN-γ)-inducible protein 10 (IP-10) and monokine induced by IFN-γ(Mig) are members of CXC-chemokine family, that are produced from macrophage/monocyte activated by IFN-γ. These chemokines especially recruit activated T cell into inflammatory site. Here, we studied effect of lipopolysaccharide (LPS), interleukin (IL)-12/IL-2 or IFN-γon induction of MIG and IP-10 in mouse brain. Methods : In order to evaluate Mig and IP-10 gene expression in brain, we injected LPS, IFN-γor IL-12/IL-2 into mice intraperitoneally, and mea-sured chemokine message in brain by RT-PCR. Results : In vivo injection of LPS induced Mig and IP-10 gene expres-sion in brain of normal mice and IFN-γknockout mouse, however, in vivo injection of IL-12/IL-2 induced Mig and IP-10 gene expression in only the brain of normal mice. IFN-γinduced chemokine expression in cultured brain cells, but anti-inflammatory drugs did not block IFN-γeffects. Conclusions : Immune stimulating agents, LPS or IL-12/IL-2 or IFN-γ, can induce T cell chemokine gene expression in brain cells, and these chemokines may play a role in T cell infil-tration in various brain diseases. J Korean Neurol Assoc 19(2):155~162, 2001 Key Words : Chemokine, Lipopolysaccharide, Interleukin-12, Interleukin-2, Interferon gamma, Brain"
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