| 측두엽간질에서 해마 경화의 진단을 위한 국소적 MRI Volumetry와 Longitudinal Regional Volume Curve |
| 홍승봉, 권혜영‡·태우석*·백철화†·김태우§·서대원*·김병준*·나동규†·변홍식† |
| 성균관대학교 의과대학 삼성서울병원 신경과학교실*,진단방사선과학교실†,가톨릭대학교 의과대학 성빈센트병원 신경과학교실‡,삼성종합기술연구원 의료전자랩§ |
| "Regional MRI Volumetry and Longitudinal Regional Volume Curve for
Detecting Hippocampal Sclerosis in Temporal Lobe Epilepsy" |
| Seung Bong Hong, M.D.*, Hye Young Kwon, M.D.‡, Woo Suk Tae*, Chul Hwa Paik, Ph.D.†,Tae Woo Kim, Ph.D.§, Dae Won Seo, M.D.*, Byoung Joon Kim, M.D.*,Dong Kyu Na, M.D.†, Hong Sik Byun, M.D.† |
| Department of Neurology & Radiology, Samsung Medical Center, Sungkyunkwan University* Neurology, St. Vincent Hospital, Catholic University Medical Electronics Laboratory of Samsung Advanced Institute of Technology |
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| Abstract |
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"Background : In order to improve MRI volumetry of hippocampus, we obtained the Longitudinal Regional Volume
Curve (LRVC) of hippocampi and compared the sensitivity of LRVC with those of conventional hippocampal volume-tries
(total and regional) in temporal lobe epilepsy (TLE). Methods : Thirty-eight normal subjects and 24 TLE patients
were included in this study. The pathology of all patients showed hippocampal sclerosis. The volume of the hippocam-pus
was measured by a manual tracing in 3 mm-thickness coronal MRI slices perpendicular to the long axis of the hip-pocampus
and a three-dimensional reconstruction. Total volume and regional volumes (anterior, middle, and posterior
1/3) of the right and left hippocampi were measured. Then, the focal hippocampal volume of each of the coronal slices
(3 mm) was plotted in a X-Y graph to obtain LRVC. The presence and pattern of HA were determined in LRVC.
Results : The mean volume of right hippocampus (2512±629 mm
3
) was bigger than that of the left one (2262.6±563.2
mm
3
) in normal subjects. The normal range of right-left total volume difference was 3.6~495.2 mm
3
. The sensitivities of
conventional volumetry, regional volumetry, and LRVC were 66.7%, 75%, and 83.3%, respectively. Eleven patients
showed diffuse HA (11/20, 55.0%) and nine had focal HA (9/20, 45.0%). In focal HA, the middle and posterior HA
were more frequent (6/9, 66.7%) than anterior HA. Conclusions : LRVC improved the sensitivity of MRI volumetry in
detecting hippocampal sclerosis and could reveal the pattern (diffuse or focal) of HA.
J Korean Neurol Assoc 19(2):125~131, 2001
Key Words : Hippocampal sclerosis, MRI volumetry, Regional volumetry, Longitudinal regional volume curve, Temporal lobe epilepsy" |
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