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Journal of the Korean Neurological Association 2001;19(1): 19-23.
한국인 허혈성 뇌졸중 환자에서 Apolipoprotein E 유전자의 발현 양상 -예비 연구
김중석, 한시령 ·정성우 ·김광수*·김종원† ·김범생
가톨릭대학교 의과대학 신경과학교실,정신과학교실*,성균관대학교 삼성의료원 임상병리학교실†
Apolipoprotein E4 Genotype in Patient with IschemicCerebrovascular Disease in Korea - A Preliminary Study
Joong-Seok Kim, M.D., Si-Ryung Han, M.D., Sung-Woo Chung, M.D., Kwang-Soo Kim, M.D.*, Jong-Won Kim, M.D.†, Beum-Saeng Kim, M.D.
Department of Neurology & Psychiatry*, College of Medicine, The Catholic University of KoreaDepartment of Clinical Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine†
Abstract
Background : The apolipoprotein E (APOE) ε4 allele is over-represented in Alzheimer’s disease, atherosclerosis, and ischemic heart disease. We investigated whether specific APOE polymorphism is a risk factor for ischemic cerebrovas-cular disease in the Korean population. Methods : We compared 98 patients with ischemic cerebrovascular disease with 209 controls similar in age and dwelling areas. APOE genotypes were determined by restriction fragment-length poly-morphism analysis. The association of the APOE with: stroke subtypes, white matter hyperintensities, lipid profiles, and potential vascular risk factors, including: age, sex, hypertension, diabetes mellitus, lipid disorders, smoking habit, car-diac diseases, presence of past history and family history of ischemic cerebrovascular diseases, was examined. Results : Overall, patients with ischemic cerebrovascular disease had no difference in APOE allele frequency with controls (p>0.05). Also, neither stroke subtypes nor white matter high signal intensities were associated with APOE polymor-phism (p>0.05). APOE ε4 carriers exhibited more frequent personal stroke histories compared with non-ε4 subjects (p<0.01). Conclusions : Our data suggests that the APOE ε4 is not associated with ischemic cerebrovascular disease in the Korean population. However, an association between APOE ε4 and personal history supports the possibility that the APOE is a susceptibility locus for the risk of ischemic cerebrovascular diseases.J Korean Neurol Assoc 19(1):19~23, 2001Key Words : Apolipoprotein E, Genotype, Ischemic cerebrovascular disease, Risk factor