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Journal of the Korean Neurological Association 1999;17(5): 741-746.
유방암과 관련된 부수종양성 Stiff-Person Syndrome 1예
방 현, 이상암 ·최은정 ·김광국 ·박성혜*
울산대학교 의과대학 서울중앙병원 신경과,진단병리과*
A Case of Paraneoplastic Stiff-Person Syndrome Associated with Breast Cancer
Hyun Bang, M.D., Sang-Ahm Lee, M.D., Eun-Jung Choi, M.D., Kwang-Kuk Kim, M.D., Sung-Hye Park, M.D.*
Department of Neurology and Pathology*, Asan Medical Center, College of Medicine, University of Ulsan
Abstract
Stiff-person syndrome (SPS) is a rare CNS disease characterized by progressive fluctuating rigidity and superim-posed muscle 넴는. We report a woman who developed stiff-person syndrome in association with breast cancer. A 55-year-old woman had progressive rigidity and intermittent muscle spasms, which predominantly occurred in her right shoulder muscles. Her symptoms were aggravated by unexpected stimuli or emotional stress, but relieved during sleep. Needle electromyography showed continuous motor unit activities in affected muscles, which were completely abol-ished by general anesthesia. An Anti-GAD antibody test was negative. She also disclosed a subacute sensory neu-ronopathy, confirmed by nerve conduction study and sural nerve biopsy. Chest CT scan revealed an enlargement of the right axillary lymph node, which was proved to be a metastatic ductal carcinoma of the right breast. The authors report the first case of paraneoplastic stiff-person syndrome with sensory neuropathy of axonal type, which is associated with breast cancer. J Kor Neurol Ass 17(5):741~746, 1999 Key Words : Stiff-person syndrome, Subacute sensory neuronopathy, Breast cancer