Microalbuminuria in non-diabetic patients 
with cerebral infacrtion

J Korean Neurol Assoc > Volume 17(2); 1999 > Article

Journal of the Korean Neurological Association 1999;17(2): 206-210.

뇌경색 환자에서 미세단백뇨의 임상적 의의

김형철, 고운산·고임석·송홍기·이병철

한림대학교 의과대학 신경과학교실

Microalbuminuria in non-diabetic patients with cerebral infacrtion

Hyoung-Cheol Kim, M.D.,Woon-San Koh, M.D., Im-Suk Koh, M.D., Hong-Ki Song M.D., Byung-Chul Lee M.D

Department of Neurology Kangdong Sacred Heart Hospital Hallym University Medical College #445 Kildong Kandong, Seoul

Abstract

Background: Microalbuminuria predicts cardiovascular events in diabetic and non-diabetic patients. But, few studies have addressed the relationship between microalbuminuria and cerebral infarction. We determined the incidence of microalbuminuria in non-diabetic subjects with cerebral infarction and investigated the relationship between urinary albumin excretion and risk factors of the stroke.
Methods: Urinary albumin excretion rate, 24 hours blood pressure monitoring, fasting serum lipid profiles, fibrinogen, fasting glucose, insulin and c-peptide were evaluated in 50 non-diabetic patients with acute cerebral infarction and matched 48 controls.
Results: Microalbuminuria was detected in 23 of 50(46%) patients with acute cerebral infarction and 4 of 48(8%) control subjects. Hypertension was present in 13 of 23(57%) microalbuminuric patients and 9 of 27(33%) non-microalbuminuric patients. In the microalbuminuric patients with cerebral infarction, diastolic blood pressure and fasting glucose were significantly greater than the control group. But, no difference in systolic blood pressure, lipid level, fibrinogen, fasting insulin and c-peptide level.
Conclusions: The prevalence of microalbuminuria in patients with cerebral infarction was higher than controls and it was associated with increased diastolic blood pressure(DBP) and fasting blood glucose(FBS). Therefore, microalbuminuria is associated with thrombogenic cerebral infarction and it was partly mediated by DBP and FBS. Key Words; Microalbuminuria, Cerebral infarction, Risk factors 서론 미세단백뇨란 reagent strip 으로는 발견이 되지 않을 정도로 미세한 양