A case of neurosarcoidosis without systemic involvement

J Korean Neurol Assoc > Volume 16(5); 1998 > Article

Journal of the Korean Neurological Association 1998;16(5): 728-731.

전신 증상없는 신경성 유육종증 1예

최승호, 김 지 언· 이 형· 임 정 근· 이 상 도· 박 영 춘

계명대학교 의과대학 신경과학교실

A case of neurosarcoidosis without systemic involvement

Seung Ho Choi, M. D., Ji Eun Kim, M. D., Hyung Lee, M. D., Jeong Geun Lim, M. D., Sang Do Yi, M. D., Young Choon Park, M. D.

Department of Neurology Keimyung University School of Medicine

Abstract

Sarcoidosis is a multisystem disorder of unknown cause. The involvement of the nervous system occurs 5% to 27% of patients with sarcoidosis, and neurosarcoidosis without systemic involvement is rare and difficult to diagnose. We present a case of 58-year-old woman with clinical features of multiple cranial and peripheral polyneuropathy with noncaseating granulomatous inflammation. Extensive testing for occult systemic sarcoidosis was negative. Sural nerve biopsy showed several perineural noncaseous granulomatous inflammation with prominent epithelioid cells. Oral steroid therapy led to some improvement. We report a patient with multiple cranial and peripheral polyneuropathy without systemic involvement, suspected sarcoidosis. Key Words : sarcoidosis, cranial neuropathy, peripheral polyneuropathy, noncaseous granulomatous inflammation