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Journal of the Korean Neurological Association 1998;16(5): 644-653.
편두통의 급성치료에 대한 수마트립탄 정제와 주사제간의 비교 연구
* 김승민d, 김장성c,김재일a, 문준식d, 박형국b, 신현길b, 이근호d, 이애영e, 주인수c, 한설희f, 허균c(가나다 순), * 김승민d, 김장성c,김재일a, 문준식d, 박형국b, 신현길b, 이근호d, 이애영e, 주인수c, 한설희f, 허균c(가나다 순)
중부권 신경과의사 협동연구팀*
A Comparative Trial of Oral and Subcutaneous Sumatriptan in Acute Treatment of Migraine: a multicenter trial
* Seol-Heui Hanb, Kyoon Huha, In Soo Jooa, Jae-Il Kimd, Seung Min Kimf, Geun Ho Leed,Joon-Shik Moonf, Ae-Young Leec, Hyung-Kook Parke and Hyun-Gil Shine(alphabetical order of last name)
Collaborative Study Group of Central Provincial Neurologists in Korea*
Abstract
Background : The efficacy of sumatriptan(SMN) in acute management of migrane has been well established. In Korea, however, a clinical study comparing the utility of oral(PO) and subcutaneous(SQ) regimen had not been conducted yet. This study was directed to compare the two regimens of SMN in terms of the efficacy as well as the adverse events in a singed-out Korea patient group. Methods : The 91 migrane patients were recruited and randomly assigned to either PO or SQ regimen as the initial treatment of acute migrane attack. Then, they were forwarded to the other regimen as an open cross-over trial. The treatment responses and adverse events were assessed and rated by the subjects. Results : Eighty one patient successfully tried at least one regimen of SMN. Overall, the proportion of excellent treatment response was 90.7%(PO) and 94.1%(SQ), with the occurrence of adverse events being 67.4%(PO) and 76.5%(SQ) respectively. In 18 patients who were able to complete cross-over procedure, the efficacy was 94.4% both in PO and SQ regimen, with the occurrence of adverse events 72.2% in both of two regimen. Although the SQ regimen tends to induce faster treatment response regardless of the cross-over completion, it bears no statistical significance. Conclusion : We conclude that the PO and SQ regimens of SMN show very comparable clinical utility in achieving therapeutic responses as well as in producing adverse events. The treatment efficacy was excellent but higher occurrence of side effects in this study, although mostly in mild degree, suggests that optimal dose adjustment strategy needs to be elaborated in Korea. Key Words : Migraine, Oral and subcutaneous sumatriptan, , Treatment response, Adverse event