Dysphagia in the patients with Parkinson's Disease

J Korean Neurol Assoc > Volume 13(4); 1995 > Article

Journal of the Korean Neurological Association 1995;13(4): 899-912.

파킨슨 병 환자에서의 연하장애

김병조, 박건우, 박민규, 고성범, 송치욱, 최재걸, 이대희

고려대학교 신경과. 내과. 핵의학교실

Dysphagia in the patients with Parkinson's Disease

Byung Jo Kim, M.D., Kun Woo Park, M.D., Min Kyu Park, M.D., Seong Beom Koh, M.D., Chi Wook Song, M.D., Jae Kul Choi, M.D., Dae Hie Lee, M.D.

Department of Neurology, Department of Internal Medicine, Department of Nuclear Medicine, College of Medicine, Korea University

Abstract

Gastrointestinal (GI) dysfunction in Parkinson's Disease is common, but its pathophysiology is poorly understood. We performed esophageal manometry, radionuclide oropharyngeal and esophageal transit study in order to obtain the objective data of the frequency of dysphagia in the patients with Parkinson's and to evaluate the subjective symptoms and motor dysfunction of oropharynx and esophagus. Seventeen idiopathic Parkinson's disease patients(7 men and 10 women) and twenty age-matched controls were subjects for esophageal manometry , radionuclide oropharyngeal(O'IT) and esophageal transit study(ETT). Among 17 patients group, 10 patients were abnormal in esophageal manometry, and 14 were abnormal in radionuclide transit time(ETT). At the results of OTT & E'IT, there is significant difference between patient group and age-matched control group(contror group OTT ;2.64+1.9, ETT ;14.33+9.4 : patient group OTT ;34.21+ 71.6, ETT ; 115.98+116. Lsec) (P < 0. 05). However, there was no significant difference between those with complain of dysphagqa and those without complain of dysphagia. Moreover, there was no correlation among the results of O'IT & EIT, the findings of esophageal manometry, those with complain. Of dysphagia, and H-Y stage. In conclusion, it showed the oropharyngeal and esophageal dysfunction in most of Parkinson's disease patients, which was not related with the severity of dysphagia. The causable lesion of dysphagia involved diffusely throughout oropharynx, body of esophagus and lower esophageal sphincter. And, esophageal manometry and radionuclide transit study might be objective tools for evaluation of dysphagia. The relationship between motor dysfunction of oropharynx and esophagus and the severity of Parkinson's disease is remained to be clear. Key Words : Parkinson's Disease, dysphagia, esophageal manometry, oropharyngeal transit time, esophageal transit time