| 사독 arginine-sterase투여가 인체의 엽록소 용해력에 미치는 영향 |
| 박정민, 임재환, 박형국, 성기범, 안무영, 신현길 |
| 순천향대학교 신경과 |
| Effect of Snake Venom :Arginine-esterase on the Fibrinolytic ?Activity
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| Jung Min Park, M.D., Jae Whan Lim, M.D., Hyung Kook Park, M.D., Ki Bum Sung, M.D., Moo Young Ahn, M.D., Hyun Kil Shin M.D. |
| Department of Neurology, College of Medicine, Soonchunhyang University |
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| Abstract |
Background and purpose:Arginine esterase(Ancrod), a thrombin-like enzyme, purified from the venoms of Agkistrodon halys, has known to cleave fibrinopeptide A from the fibrinogen and lead to circulation of soluble noncross-linked ""ancrodfibrin', which stimulates endogenous T-PA release.Many authors have suggested clinical applicability of this enzyme,but clinical studies on its fibrinolytic action has been insufficient.Thus we studied the influence of this enzyme on fibrinolytic activity in cerebral infarction.
Method:We observed the change of euglobulin fibrinolytic activity, t-PA antigen, t-PA
activity,
fibrinopeptide A, fibrinogen, FDP and D-dimer, during 12 hours after a bolus
intravenous administration of 0.25 unit of the arginine esterase to the 9 patients with
cerebral infarction.
Result:There was no change of the euglobulin fibrinolytic activity, fibrinopeptide A and
t-PA Ag but there was significant increase in both t-PA activity and FDP, D-dimer
and significant decrease in fibrinogen.
Conclusion:Our result suggest that arginine esterase converts fibrinogen to a fibrin
polymer which has a increased susceptibility to lysis by plasmirl This enzyme seems to
amplify T-PA activity through the consequent increase in FT)P, because there is no
increase in the euglobulin fibrinolytic activity, fibr'mopeptide A and t-PA Ag suggesting
direct T-PA release. Arginine esterase, having action of effective defibrinogenation and
safe fibrinolysis,could be used for the thrombus related disease. |
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